The impact of Covid-19 in developing countries is clearly visible in various aspects of people’s lives. The World Health Organization (WHO) reports that these countries face major challenges in maintaining public health and strengthening their health systems. One of the main impacts felt is the increase in death rates due to non-communicable diseases, such as diabetes and hypertension, which should be managed well in a functional health system. In addition, the pandemic has caused a severe economic crisis. Many economic sectors are experiencing a decline, especially in countries that rely heavily on tourism and exports. The domino effect of this economic pressure is increasing poverty, which has a direct impact on people’s access to health services. WHO notes that 70% of people in developing countries do not have adequate access to basic health services. Vaccination is one of the main focuses in handling Covid-19 in developing countries. However, vaccine distribution is often hampered by logistical problems and poor infrastructure. WHO launched the COVAX program to help these countries get fair access to vaccines. Nevertheless, there are still many challenges faced. Distrust of vaccines has also emerged, caused by misinformation and lack of understanding regarding the safety and effectiveness of vaccines. Health education is very important in overcoming this problem. WHO, through its various initiatives, is trying to increase public understanding of the importance of vaccination and other Covid-19 prevention measures. Additionally, developing countries need to strengthen their local capacities in research and development, to ensure that they can better handle future health crises. Mental health has also become an increasingly raised issue during the pandemic. WHO is concerned about the increase in cases of depression and anxiety occurring in society due to prolonged stress during lockdown and economic uncertainty. Psychosocial support programs need to be implemented to help people cope with the emotional impact of the pandemic. In the context of child health, WHO warns of a decline in routine immunization in developing countries. With the focus on Covid-19, immunization for other diseases risks being overlooked, which could result in outbreaks of preventable diseases. Therefore, it is important for the government to maintain the immunization program even in a health emergency. Sustainability of health systems in developing countries is key to rapid recovery. Investments in public health and infrastructure are crucial steps. WHO recommends increasing international collaboration to help these countries build the capacity needed to respond not just to Covid-19, but also future health crises. Continuous monitoring and evaluation of existing health programs is also important. With the right data and thoughtful analysis, countries can make better decisions about necessary health interventions. Determining evidence-based policies will save resources and ensure that every action taken truly provides benefits to society. Ultimately, synergy between governments, international organizations and civil society is needed to create a healthy environment. Facing the challenges posed by Covid-19, a comprehensive approach to the root of the problem is vital to achieving health security in developing countries.